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Cyclin-dependent kinase 8 (Cdk8) is a kinase that associates with Cdks, mainly Cdk7, and plays an important role in the brain. Although Cdk8 is ubiquitously expressed in the brain, its role in developing and mature brain is not clear. Previous study showed that deletion of Cdk8 in the liver enhanced cell proliferation and induced liver tumor. Recently, it was reported that deletion of Cdk8 in murine neural stem cells, at least in the case of Shh::Cre line, causes significant cell cycle exit, although its effect was less prominent than that of Cdk4 deletion. In this study, we used Nestin::Cre line to examine the effect of Cdk8 deletion on cell proliferation in the cerebellum, because granule neurons in the cerebellum are derived from progenitor cells that show asymmetric divisions. Deletion of Cdk8 from progenitor cells had little effect on the cell cycle exit of these cells, but had a dramatic effect on the proliferation of granule neurons. We conclude that
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