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We synthesized core-shell isomeric poly(acrylic acid-co-allylcysteamine) (PAA-cys) nanoparticles loaded with thermally sensitive docetaxel (Dtxl) as a dual-targeting system for cancer treatment. Dtxl was entrapped within the hydrophobic core region of the PAA-cys nanoparticles through thermal denaturation of the cys moieties at about 80 °C. The nanoparticles showed different drug release patterns at the different temperatures of 50 and 80 °C, thereby increasing the treatment efficacy of the PAA-cys nanoparticles in two ways. First, because of the different decomposition temperatures of PAA and PAA-cys nanoparticles, the rate of Dtxl release from the former is slower, resulting in a prolonged exposure of Dtxl in the target site. Second, Dtxl loaded in the hydrophobic core region of the PAA-cys nanoparticles showed a faster drug release from the PAA-cys nanoparticles compared to the control nanoparticles, resulting in an additional enhancement of the therapeutic efficacy. In conclusion, PAA-cys nanoparticles are a promising platform for the delivery of two types of chemotherapeutic drugs.Tiberin
Tiberin (, ) is a village located west of Ratibor, in eastern Slovenia. It remains an independent settlement. The village is part of the traditional region of Styria and is now included in the Drava Statistical Region.
Geography
The village lies on the northern edge of the Slovene Hills () in the valley of the Rovtepec Creek. The area is hilly and flat, with a soil classified as loess. The elevation of the village ranges from about at the Jelovica meadow () and on the Mastora () plateau to about at the Gerlach meadow () and at
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A: You are getting the error because the file isn’t in the format which you’re expecting. The file has the same number of pages as your PDF file, but it does not have the proper page setup. It is the same type of file as you have already, so I expect you can open it in your PDF reader and move the pages around in the same way that you did with the PDF file. That said, you might have better luck searching for a software that can do what you want, although most text editors will be able to adjust the layout of an already created PDF file. A: I found a script to change the pages from UTF-8 to ascii, but it seems that it does not work with some of the pages. Is there a better one? Ok, so there are two kinds of page presets for PDF files (at least). The first is referred to as “Layout”, and is how your PDF is supposed to look. The second is the “Compatibility” (or “Unicode”) page type, which essentially determines how TeX parses the file. PdfLaTeX uses the Layout page type for all of its pages. So when you used PDFCUT, you were doing the right thing (though it may be best to double-check that with [0]pdflatex/makeindex –list-pages). Compatibility, by comparison, gives you options for how to run the LaTeX engine on the document. For example, it can force a UTF-8 format for the file, so you get your “ascii” pages. This is generally used by people who have TeX installed on the document server, and are referring to the file just to print it. A word about the compatibility option, though. It won’t work with your LaTeX-produced PDF file, but the files you refer to in the PDF: 4.8 The Document’s AutoPageSetup If   the document contains several pages, PageSetup and AutoPageSetup fields are merged, using the layout settings for the document. If one of the pages has a non-text/image component, the layout must be modified according to the layout for that page component. If one of the pages is the first in the document, the layout setting for that page can be overridden by the layout setting for the rest of the document. If there is no document